The efficacy and safety of therapeutic lung lavage for exogenous lipoid pneumonia: A systematic review

Abstract Introduction and objectives Exogenous lipoid pneumonia (ELP) is a lung inflammatory disease with low prevalence has the feature of external lipid substances presented in alveoli. Therapeutic lavage (segmental bronchoalveolar whole lavage) been gradually recognized as an important therapy for disease. There was no comprehensive summary on its efficacy safety. Methods We searched PubMed, Embase, Cochrane Library, CNKI, Wanfang Database, clinicaltrials.gov, references included studies. After study selection, data extraction quality assessment, we performed qualitative description current data. Results 90 ELP patients from 25 case reports 8 series Eighty‐four (93.3%) received segmental six (6.7%) lavage. Eighty‐seven (96.7%) got clinical improvement after lavages, while three (3.3%) had eventually died. The follow‐up status reported 29 patients, whom 24 remained well without any use drugs 4 some periods corticosteroids. One patient endured recurrence. radiological change 72 41 (56.9%) full resolution until last follow‐up. Two studies acute pulmonary edema transient hypoxemia during lavages. Conclusions might be effective safe long‐term benefits ELP. Current were all relatively high risk bias. Prospective controlled are needed to explore actual efficacy, safety, individualized indications, optimized treatment procedures therapeutic